Abstract : Background: An ideal neuromuscular blocking agent should have a high degree of potency, rapid onset of
action and short duration of action. It should not cause haemodynamic changes through releasing histamine,
ganglion block, anti-muscarinic effects on heart or sympathomimetic action. This study was designed to
compare the effect of cisatracurium with or without magnesium pretreatment on neuromuscular blockade
and hemodynamics in cardiac surgery patients on cardiopulmonary bypass with objective to assess and
compare intubation conditions and timing of intubation in minutes and assess and compare clinical duration
of blockade, haemodaynamics variable and side effect if any.
Materials and Methods: Hospital based, prospective, randomized double blind observational study. Total
60 patients included in the study (30 in each group). Group A Pretreatment with mgso 4(50mg/kg BW in
100ml NS 10 mints before general anesthesia (GA) and muscle relaxant injection Cisatracurium 0.2mg/kg.
Group B received 100ml NS 10 mints before general anesthesia (GA) and muscle relaxant injection
Results: The mean onset of action of injection cis-atracurium after intubating dose in group A was 4.
27+/1.68 minutes as compared to 5.48+/-1 minutes in group B(p-value
of action was significantly less in group A as compared to group B. Duration of action of intubating dose
of cisatracurium was prolonged by pre-treatment of Mgso4. Haemodynamic parameters were comparable
and there was no statistically significant difference among both the groups. No side effect reported in our
Keywords: Cisatracurium, Magnesium sulphate, Cariopulmonary by pass, Peripheral nerve stimulator.