International Journal of Clinical Biochemistry and Research

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

Prevalence of hypoparathyroidism, growth retardation in patients of beta-thalassemia major

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Naresh Manne, Sandeep Kumar Yadav, Bharath Kumar Gupta, Saurabh Singhal, Archana Dubey

Page no : 158-163

Abstract : Background: Beta-Thalassemia is a genetic disorder which is associated with a lot of complications. Frequent blood transfusions result in increased iron deposition in various tissues leading to dysfunction of many vital organs. Endocrine disorders constitute a major part of such complications increasing the morbidity of thalassemia manifold in the affected patients. Early diagnosis of hypoparathyroidism (HPT) could prevent other severe disorders such as Tetany, seizures, osteopenia, and osteoporosis. Growth retardation can occur as complication of thalassemia as early as the 1st or 2nd year of life but these abnormalities more prominent after the 6 – 8 years of life. Aim & Objectives: The aim of this study was carried out to determine; 1. The prevalence of (HPT) and Growth retardation in patients with beta and to correlate them with serum , calcium, phosphorus and alkaline levels; 2. The relationships of growth failure with certain variable including age, serum , mean hemoglobin level and gender of the patients. Materials and Methods: This is a descriptive research study which was conducted on 200 subjects (100 cases and 100 controls) in the age group of 10-25 years who had visited the OPD/IPD of Subharti Medical College & affiliated Hospitals, . The cases included were with confirmed diagnosis of beta major, with regular blood transfusions and serum levels >2000 /ml irrespective of therapy. Results: Out of 100 patients, was diagnosed in 18% patients, Growth retardation/ Short stature 93% and Weight loss was found in 93% patients. The mean age at diagnosis was 12.6 years (range 11-16 years), mean serum calcium was 7.53 mg/ (range7.58-9.04 mg/), mean serum was 5831.0 /ml (range 2000-8,064 /) and mean serum phosphate was 5.63 mg/ (range 4.50-7.73 mg/). Serum parathyroid hormone (PTH) levels were low in most of the patients. Short stature was observed in most of the patients, while it was found normal in control subjects. Significant (HPT) observed along with growth retardation in beta patients (p < 0> Keywords: Hypoparathyroidsm, Growth retardation, b - Thalassemia, Parathormone.