International Journal of Clinical Biochemistry and Research

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

Study of evaluation of renal function in subclinical hypothyroid patients

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Gaurang K Anandpara, Mittal A Pancha, Yashkumar P Rawal, Shobha Chokshi

Page no : 185-190

Abstract : Subclinical hypothyroidism (SCH) is evaluated as an increased serum thyroid-stimulating hormone (TSH) above the given upper limit of the reference range, with free thyroxine (free T4) and free triiodothyronine (free T3) within the reference range. Thyroid hormones play major role in the growth, development and physiology of the renal system. The study was performed to evaluate renal functions in SCH cases. The study was conducted at Smt SMS Multispecialty hospital. 50 SCH and 50 overt hypothyroidism (OHT) cases, 100 euthyroid patients (ET) were enrolled in the study. Thyroid function test, serum creatinine and eGFR were measured in all the three groups. The result shows that there was a definitive trend of increased serum creatinine from euthyroid group to SCH group and finally to OHT group and definitive trend of decreased eGFR from euthyroid group to SCH group and finally to OHT group. Among the three groups, there are higher percentage of patients having high serum creatinine and low eGFR belongs to SCH and OHT group in comparison to ET group. Our result showed a significant positive correlation of TSH with serum creatinine in cases of SCH and OHT and significant negative correlation of TSH with eGFR in cases of SCH and OHT. Finding of our study suggests that renal function and thyroid function are interrelated with each other in SCH cases. SCH patients should be monitored for renal parameters regularly to prevent long term complications. Early diagnosis and early treatment of the disease and can increase the quality of life. Keywords: Subclinical hypothyroid, Overt hypothyroid, Euthyroid, Estimated Glomerular Filtration Rate, (eGFR).