International Journal of Clinical Biochemistry and Research

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

Elevated serum homocysteine as a potential marker for cardiovascular changes in overt hypothyroidism

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Dileep Khubya, Nanda K, Simant Baliarsingh, Pratibha K, V Vijayakumari

Page no : 207-211

Abstract : Overt hypothyroidism(HO) defined as high Thyroid Stimulating Hormone (TSH) levels with low levels of free thyroxine (FT4) and / or free triiodothyronine (FT3). Hypothyroidism is associated with an increased risk for atherosclerotic cardiovascular disease. Serum Homocysteine (Hcy) is a independent risk factor for atherosclerosis and cardiovascular diseases. Elevated plasma homocysteine levels have been reported in overt hypothyroidism. Aim: To study levels of Hcy in relation to TSH, FT4 and FT3 levels in overt hypothyroid patients compared to control groups and correlation between Hcy and thyroid hormones. Materials and Methods: This study included 50 female overt hypothyroid cases with age group between 18-50 years and 50 healthy females controls with same age group. Serum homocysteine was estimated by Homocysteine Enzyme Assay in Cobas Integra 400 plus. TSH, FT4 & FT3 estimated by CLIA method using Beckman coulter Access 2. Parameters of cases and controls are compared using unpaired ‘t’ test and the association between parameters is assessed by using Pearson’s correlation. Results: There is a significant increase in Serum Hcy levels 19.24 7.15 mmol/L and TSH levels 30.91 10.21 mIU/ml respectively (p value Hcy was positively correlated with TSH and negatively correlated with FT4 and FT3. Conclusion: Thus, from our study we can conclude that serum Hcy levels can be used as a marker, which points towards the possible risk factor for atherosclerosis and cardiovascular diseases in Overt hypothyroid patients. Keywords: Atherosclerosis, Cardiovascular disease, Homocysteine, Overt hypothyroidism.