Abstract : Introduction: A main cause of morbidity and mortality in Worldwide is Diabetes mellitus. Acute phase
reactant like hs-CRP acts as a non-specific marker of inflammation. Action of insulin becomes resistant on
peripheral tissues of human body in Insulin resistance (IR). Pathogenesis of type - 2 diabetes mellitus is
strongly linked with Insulin resistance.
Aim: The aims of this study is to assess between type-2 diabetic subjects and non-diabetic healthy subjects
about the status of pro- inflammatory markers as hs-CRP and IR.
Material and Methods: This study was conducted in Govt. Medical College, Shivpuri (MP). A total
of 200 subjects were included in this study. Out of these, 100 were type-2 diabetes mellitus cases and
100 were non diabetic healthy subjects. They were evaluated by measurement of several physiological
and biochemical parameters such as Blood Pressure, Body Mass Index, blood parameters as –Fasting
Blood Sugar, Post Prandial, HbA1c, Triglyceride, Total Cholesterol, Low Density Lipoprotein, Very Low
Density Lipoprotein, High Density Lipoprotein, high sensitive-C Reactive Protein, Fasting Insulin level
and Homeostasis Model Assessment of Insulin Resistance.
Result: hs-CRP is usually extensively increased in diabetic cases. The raised level of hs-CRP is noteworthy
in diabetes mellitus cases as compared to healthy subjects. Serum Total Cholesterol, Triglyceride, VLDL
and LDL levels were highly increased, whereas HDL level were significantly lower in patients of diabetes
when compared to controls. hs-CRP had considerable positive correlation with insulin resistance markers
and whereas negative associations with insulin sensitivity markers.
Conclusion: hs-CRP and IR were strongly related with the metabolic variables and markers of Type- 2
diabetes mellitus subjects with and without complication. Results of this study show that hs-CRP can play
a major role in the early detection of IR in diabetes mellitus cases.
Keywords: High sensitivity C-reactive protein, (hs-CRP), Insulin resistance (IR), Homeostasis model assessment for
Insulin resistance (HOMA-IR).