International Journal of Clinical Biochemistry and Research

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

A study of uric acid levels in serum and pleural fluid as to differentiate between transudate and exudate in pleural effusion

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Irigu V Kumar, N Vani, Kishore Y Jothula

Page no : 216-220

Abstract : Context: Pleural effusion is an excessive accumulation of fluid in the pleural space lying between the lung and chest wall. In normal condition, pleural space contains 0.1 to 0.3 ml/kg body weight of fluid (nearly about 10ml.of fluid on each side) between parietal and visceral pleura. Aims: To assess the usefulness of uric acid levels in both serum and pleural fluid in differentiation between transudates and exudates in pleural effusion. Settings and Design: Hospital based cross sectional study. Materials and Methods: A total of 250 patients with pleural effusion were selected for the study. Uric acid level, total protein, albumin and LDH levels of Serum and pleural fluid were measured from the participants. Statistical analysis used: Data analysis was done by using SPSS ver.23 and presented in proportions and student unpaired‘t’ test was used to compare means. Results: The mean uric acid level in serum and pleural fluid was 7.6260.06 mg /dL and 10.270.07 mg /dL respectively in transudates, whereas in exudates it was 4.890.04 mg /dL and 2.490.06 mg /dL and the differences were found to be statistically significant. Conclusion: Measurement of uric acid in association with Total proteins, LDH, Albumin will aid in differentiating the transudates and exudates in pleural effusion. Key Message: Uric acid levels can be a better biomarker and cost-effective method to differentiate transudate and exudative pleural effusion easily, to diagnose and for better management of the patient. Keywords: Albumin, Exudate, LDH, Pleural effusion, Transudate, Uric acid.