International Journal of Clinical Biochemistry and Research

Innovative Education and Scientific Research Foundation

Email : editor@iesrf.org
Registered Under Government of India NGO – Indian Trust Act 1882

Comparative evaluation of enzymatic and non-enzymatic antioxidants in alzheimer dementia

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Balasaheb H Jadhav, Madhav G Kalekar, Syed Abdul Jaweed, Poornima Shelke

Page no : 232-237

Abstract : The senile dementia is a neurodegenerative disease characterized by loss of memory, attention and cognitive functions. The oxidants- antioxidant plays important role by several mechanism by reducing toxic Amyloid-b in neurons The Alzheimer’s disease is due to Amyloid-b deposition in the brain and production of neurofibrillary tangles. Amyloid-b induces reactive oxygen species in brain of Alzheimer dementia patients. In the present study we evaluated the levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin B6 in Alzheimer dementia patients. It has been observed lower levels of Enzymatic, Non-Enzymatic Antioxidants and increased serum levels of malondialdehyde significantly in Alzheimer’s dementia patients as compared to healthy controls (p < 0> oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia. Serum levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin B6 and Malondialdehyde (indicator of Lipid peroxidation) were measured using standard methods in 50 healthy controls and 50 Alzheimer’s dementia patients. Keywords: Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), MDA (Malondialdehyde), Ascorbic acid (Vit C), Alpha-Tocopherol (Vit E), Amyloid-b (Ab), Reactive oxygen species (ROS).