Abstract : The senile dementia is a neurodegenerative disease characterized by loss of memory, attention and
cognitive functions. The oxidants- antioxidant plays important role by several mechanism by reducing toxic
Amyloid-b in neurons The Alzheimer’s disease is due to Amyloid-b deposition in the brain and production
of neurofibrillary tangles. Amyloid-b induces reactive oxygen species in brain of Alzheimer dementia
patients. In the present study we evaluated the levels of Superoxide dismutase, Glutathione peroxidase,
Catalase, Vitamin C and Vitamin E and Vitamin B6 in Alzheimer dementia patients. It has been observed
lower levels of Enzymatic, Non-Enzymatic Antioxidants and increased serum levels of malondialdehyde
significantly in Alzheimer’s dementia patients as compared to healthy controls (p < 0>
oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia. Serum
levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin
B6 and Malondialdehyde (indicator of Lipid peroxidation) were measured using standard methods in 50
healthy controls and 50 Alzheimer’s dementia patients.
Keywords: Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), MDA (Malondialdehyde), Ascorbic acid (Vit C), Alpha-Tocopherol (Vit E), Amyloid-b (Ab), Reactive oxygen species (ROS).