International Journal of Clinical Biochemistry and Research

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

Castelli risk index-1 and atherogenic coefficient are better predictors of cardiometabolic risk in patients with hypothyroidism

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Sasikala T, Kalyan Goswami

Page no : 254-259

Abstract : Hypothyroidism resulting from a deficiency of thyroid hormones may be associated with dyslipidaemia. Since altered lipid profile is quite important in predicting CVD risk, therefore the present study aimed to investigate any possible association between the levels of certain lipid indices with thyroid profile and their diagnostic ability of cardiometabolic syndrome in patients with hypothyroidism. Material and Methods: A cohort of 40 female patients diagnosed with hypothyroidism was included as cases and thirty age and gender matched healthy females were recruited as controls. Fasting blood samples were collected for analysis of thyroid hormones, cholesterol, triglycerides and high density lipoprotein cholesterol levels by Chemiluminescence immuno-assay, and enzymatic colorimetric methods respectively. Differences in all between groups were tested using parametric independent sample T test. Pearson’s correlation or Spearman rank correlation analysis was done to study the correlations among the parameters as appropriate. Receiver operative characteristic (ROC) curve analysis was performed to study diagnostic utility of parameters. Results: Lipid indices were found to be significantly increased in patients with hypothyroidism when compared to the controls. Castelli risk index-I (CRI-I), CRI-II, atherogenic coefficient (AC) and atherogenic index of plasma (AIP), were found to be significant positively correlated with low density lipoprotein cholesterol (LDL) (r=0.923, p=0.0001, r=0.935, p=0.0001,r=0.970, p=0.0001 and r=0.382, p=0.0001 respectively). The ROC curve analysis of lipid indices for cardiometabolic risk reveals that AUC for CRI-I and AC was high and statistically significant than other lipid parameters. Conclusion: The present study suggests that in addition to routine lipid investigations the inclusion of lipid Indices especially CRI-I, AC, were better indices for screening of early detection of cardiometabolic risk in female patients with hypothyroidism. Keywords: Atherogenic index of plasma, Castelli risk index 1, Atherogenic coefficient, Cardiometabolic risk.