Abstract : Hypothyroidism resulting from a deficiency of thyroid hormones may be associated with dyslipidaemia.
Since altered lipid profile is quite important in predicting CVD risk, therefore the present study aimed to
investigate any possible association between the levels of certain lipid indices with thyroid profile and their
diagnostic ability of cardiometabolic syndrome in patients with hypothyroidism.
Material and Methods: A cohort of 40 female patients diagnosed with hypothyroidism was included as
cases and thirty age and gender matched healthy females were recruited as controls. Fasting blood samples
were collected for analysis of thyroid hormones, cholesterol, triglycerides and high density lipoprotein
cholesterol levels by Chemiluminescence immuno-assay, and enzymatic colorimetric methods respectively.
Differences in all between groups were tested using parametric independent sample T test. Pearson’s
correlation or Spearman rank correlation analysis was done to study the correlations among the parameters
as appropriate. Receiver operative characteristic (ROC) curve analysis was performed to study diagnostic
utility of parameters.
Results: Lipid indices were found to be significantly increased in patients with hypothyroidism when
compared to the controls. Castelli risk index-I (CRI-I), CRI-II, atherogenic coefficient (AC) and atherogenic
index of plasma (AIP), were found to be significant positively correlated with low density lipoprotein
cholesterol (LDL) (r=0.923, p=0.0001, r=0.935, p=0.0001,r=0.970, p=0.0001 and r=0.382, p=0.0001
respectively). The ROC curve analysis of lipid indices for cardiometabolic risk reveals that AUC for CRI-I
and AC was high and statistically significant than other lipid parameters.
Conclusion: The present study suggests that in addition to routine lipid investigations the inclusion of lipid
Indices especially CRI-I, AC, were better indices for screening of early detection of cardiometabolic risk
in female patients with hypothyroidism.
Keywords: Atherogenic index of plasma, Castelli risk index 1, Atherogenic coefficient, Cardiometabolic risk.