Indian Journal of Clinical and Experimental Ophthalmology

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

A study to show retinal neurodegeneration association with peripheral nerve conduction in diabetic (type-ii) patients

Article : Open access

Article type : Research Article

Volume : 6

Issue : 2

Year : 2020

Author : S P Singh, Brijesh Singh Yadav, K J Singh, Aparajita Chaudhary, Vinod Kumar Singh

Page no : 159-164

Abstract : Objectives: Aim of this study was to show the association between retinal neuro-degeneration with peripheral nerve conduction in diabetic (type-II) patients. Materials and Methods: A total of 30 diabetic patients age ranging from 35-70 years with mild/moderate non proliferative diabetic retinopathy (NPDR) and 30 non diabetic control were studied at M.D. eye hospital Prayagraj R.I.O., Prayagraj. Spectral-Domain -OCT imaging was performed with the cirrus HD-OCT (Version; Carl Zeiss Meditec, Inc.), along with nerve conduction study test. Results: Mean ganglion cell inner Plexiform thickness was assessed in diabetic patients with neuropathy (Group-A) and without neuropathy (Group-B) in eyes. The difference between mean thickness of these two groups was found to be significant at same level of significance and confidence interval (t=4.61, p=0.014). Both the significant difference indicate that diabetic patients with neuropathy (Group A), were associated with lower mean of “ganglion cell–inner Plexiform thickness” in both the eyes as compared to without neuropathy patients (Group B). Conclusion: In this study we found a positive correlation between decrease in Ganglion cell-inner plexiform layer (GC-IPL) thickness and decrease peripheral nerve conduction in diabetic patients. Decrease in Ganglion cell-inner plexiform layer (GC -IPL) is predictive of early retinal neurodegeneration in diabetic patients, according to our study. Keywords: Diabetic retinopathy, Electrodiagnostic nerve conduction test GC-IPL thickness, Peripheral neuropathy.