Abstract : Klebsiella Pneumoniae is one of the most common causes of nosocomial respiratory tract infections all
over the world. Unfortunately, it is developing resistance to many antibiotics. This study was carried out
in a teaching hospital for determining the prevalence and pattern of antibiotic sensitivity among Klebsiella
pneumoniae isolated from sputum samples of hospital acquired respiratory tract infection.
Materials and Methods: A total of 154 samples were included in the present study. Klebsiella Pneumoniae
were isolated in (21.52%) samples and identified by standard microbiological techniques. Antibiotic
susceptibility testing was done by the Kirby-Bauer disc diffusion method and interpreted as per CLSI
Results: Isolated strains were sensitive to Amikacin (70%) Levofloxacin (70%) Gentamicin (65%)
Chloramphenicol (65%) and resistant to Ampicillin (98.72%) Co-trimoxazole (87.5%) Ceftriaxone (85%)
Tigecycline (85%) Tobramycin (85%).
Conclusion: This study may help to formulate local antibiotic policy as a part of rational antibiotic therapy
for hospitals; this may reduce the development of multi-drug resistance.
Keywords: Klebsiella Pneumoniae, Sputum, Antibiotic resistance, Antibiotic susceptibility, Nosocomial infection.