Indian Journal of Pathology and Oncology

Innovative Education and Scientific Research Foundation

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Registered Under Government of India NGO – Indian Trust Act 1882

Histomorphological spectrum of gall bladder lesions, relation to p53 expression

Article : Open access

Article type : Research Article

Volume : 7

Issue : 2

Year : 2020

Author : Marapaka Pavani, J Anunayi, N Vivekanand, Ashok Kumar Deshpande

Page no : 235-242

Abstract : Introduction: Gall bladder lesions include the varied spectrum of lesions encompassing inflammatory, benign, premalignant and malignant conditions. Progression from benign to malignant change is a complex process. The pathological importance of chronic inflammation leading to neoplasia has come into prominence in recent years. Multiple mechanisms are involved in the carcinogenesis and the most commonly disrupted gene is the p53 gene. Materials and Methods: In our prospective study, of three consecutive years duration a total of 262 specimens which included inflammatory, premalignant, and malignant lesions of the gall bladder were received. Immunohistochemical analysis with a p53 antibody was done on selected 60 specimens according to our inclusion criteria. Results: Of the received specimens majority (84.7%) were inflammatory lesions followed by precursor lesions (10.7%) and malignant lesions (4.5%). Chronic cholecystitis with cholelithiasis is the predominant lesion accounting for 33% of the cases. P53 expression was observed in 50% of malignancies and was not seen in any of the premalignant conditions. 11.8% of inflammatory lesions with thickened wall showed p53 expression. Conclusion: The most common histopathological diagnosis was chronic cholecystitis. Chronic inflammation is a major risk factor for malignancy. Careful pathological examination of gallbladder specimens should be done as the neoplastic process may present silently as cholecystitis. P53 expression in chronic inflammatory conditions indicates an important role of inflammation in chronic cholecystitiscarcinoma sequence. Early detection of p53 mutation by Immunohistochemical analysis, and regular follow up aid in optimal patient management. Keywords: Gall bladder, Cholecystitis, p53.