Author : Neeraj Srivastava, Mayank Singh, D Nath, Chhaya Rani Chevra, Niharika Rawat
Abstract : Background: Metabolic syndrome is constellation of many different disorders. The common conditions
associated with metabolic syndrome are obesity, hypertension, dyslipidemia and insulin resistance. These
conditions do play some role in developing cardiovascular disease beyond traditional risk. Metabolic
syndrome have been commonly seen in patients of many skin diseases including psoriasis, lichen planus,
acne inversa and even in skin malignancies. In chroni skin disorder and even in metabolic syndrome chronic
inflammation has been shown to play some role in the pathogenesis of disease. The present study is
designed with a view to know any association between skin diseases especially psoriasis and metabolic
syndrome, as well as expression of C-reactive protein in psoriasis and other skin diseases in this region.
Materials and Methods: Present study was conducted on 76 histopathologically confirmed cases of
Psoariasis & Lichen Planus and 70 age and sex matched controls with skin lesions other than psoriasis
and lichen planus. For metabolic syndrome criteria proposed by National cholesterol education programme
(NCEP) ATP III was used. Triglycerides, HDL cholesterol, Blood sugar and CRP level was quantitatively
determined on serum/plasma of patients. Chi square test and SPSS 19.0 software was used for statistical
Results: Among psoriasis patients 18/52 had metabolic syndrome while this figure was low in lichen
planus patients 7/24. The incidence of metabolic syndrome with skin disease was high as compared
to control population and it was also statistically significant. Cases (psoriasis and lichen planus) with
metabolic syndrome had high CRP value 61.1% (11/18) and 57.1% (04/07) respectively as compared to
control 12.8% (09/71) and also displayed significant association.
Conclusion: It was concluded from this study that metabolic syndrome is an important co-morbidity with
psoriasis and lichen planus which requires screening to avoid complications in later life.
Keywords: Psoriasis, Lichen Planus, Metabolic syndrome, CRP.